Complete sequence analysis shows that the hemagglutinins of the H0 and H2 subtypes of human influenza virus are closely related
Identifieur interne : 002736 ( Main/Exploration ); précédent : 002735; suivant : 002737Complete sequence analysis shows that the hemagglutinins of the H0 and H2 subtypes of human influenza virus are closely related
Auteurs : Alan L. Hiti [États-Unis] ; Alan R. Davis [États-Unis] ; Debi P. Nayak [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1981.
English descriptors
- Teeft :
- Acid sequence, Aiwsn, Amino, Amino acid, Amino acid sequence, Amino acid sequence homology, Amino acid sequences, Amino acids, Antigenic, Antigenic drift, Arginine, Basic architecture, Carboxy terminus, Cleavage, Codon, Compans, Complete nucleotide sequence, Cysteine, Disulfide, Dopheide, Elsevier, Gething, Havl, Hemagglutinin, Hemagglutinin gene, High degree, Homology, Human influenza virus, Influenza, Influenza virus, Influenza virus hemagglutinin, Laver, Mdbk cells, Nayak, Noncoding region, Nucleotide, Nucleotide sequence, Other honl strains, Other subtypes, Pairing, Polypeptide, Prepeptide, Proteolytic cleavage, Skehel, Subtype pairings, Subtypes, Virology, Virus, Waterfield.
Abstract
Abstract: The complete sequence of the hemagglutinin (HA) gene from the A/WSN/33 strain (H0N1) of human influenza virus has been determined and compared with four other HA sequences: the human H2 strain A/Japan/305/57, the avian Havl strain A/FPV/Rostock/34, and the human H3 strains A/Memphis/102/72 and A/Victoria/3/75. The A/WSN HA gene is 1775 nucleotides in length coding for 565 amino acids. The plus strand sequence contains a noncoding region of 32 nucleotides at the 5′ end followed by the coding region of 1695 nucleotides and a 3′ noncoding region of 48 nucleotides (including the UGA nonsense codon). The amino acid sequence derived from the nucleotide sequence shows the presence of a 17 amino acid long “signal” prepeptide at the amino terminus followed by an HA1 of 325 amino acids, a single arginine connecting residue, and an HA2 of 222 residues at the carboxy terminus. The comparison with other subtypes reveals many conserved features throughout the primary sequence in all strains and reinforces the argument for a basic architecture required of the entire hemagglutinin molecule. Comparison of the H0 and H2 HAs (minus the “signal” prepeptide) shows a 67% amino acid sequence homology, which is the highest among the subtypes, suggesting a close geneologic relationship between the two.
Url:
DOI: 10.1016/0042-6822(81)90658-9
Affiliations:
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The A/WSN HA gene is 1775 nucleotides in length coding for 565 amino acids. The plus strand sequence contains a noncoding region of 32 nucleotides at the 5′ end followed by the coding region of 1695 nucleotides and a 3′ noncoding region of 48 nucleotides (including the UGA nonsense codon). The amino acid sequence derived from the nucleotide sequence shows the presence of a 17 amino acid long “signal” prepeptide at the amino terminus followed by an HA1 of 325 amino acids, a single arginine connecting residue, and an HA2 of 222 residues at the carboxy terminus. The comparison with other subtypes reveals many conserved features throughout the primary sequence in all strains and reinforces the argument for a basic architecture required of the entire hemagglutinin molecule. Comparison of the H0 and H2 HAs (minus the “signal” prepeptide) shows a 67% amino acid sequence homology, which is the highest among the subtypes, suggesting a close geneologic relationship between the two.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Hiti, Alan L" sort="Hiti, Alan L" uniqKey="Hiti A" first="Alan L." last="Hiti">Alan L. Hiti</name></noRegion><name sortKey="Davis, Alan R" sort="Davis, Alan R" uniqKey="Davis A" first="Alan R." last="Davis">Alan R. Davis</name><name sortKey="Nayak, Debi P" sort="Nayak, Debi P" uniqKey="Nayak D" first="Debi P." last="Nayak">Debi P. Nayak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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